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TA-02

Chemical Structure : TA-02

CAS No.: 1784751-19-4

TA-02 (p38 MAPK inhibitor TA02)

Catalog No.: PC-42059Not For Human Use, Lab Use Only.

TA-02 is a potent p38 MAPK inhibitor with IC50 of 20 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TA-02 is a potent p38 MAPK inhibitor with IC50 of 20 nM.
TA-02 inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis, and increases ATF-2 and MEF2C during cardiac differentiation.

Physicochemical Properties

M.Wt 333.3341
Formula C20H13F2N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Pyridine, 4-[2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-

References

1. Laco F, et al. J Mol Cell Cardiol. 2015 Mar;80:56-70.

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