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Chemical Structure : TAK-041
CAS No.: 1929519-13-0
Catalog No.: PC-72146Not For Human Use, Lab Use Only.
TAK-041 (Zelatriazin, NBI-1065846) is a potent, selective, brain-penetrant GPR139 agonist with EC50 of 22 nM (CHO-T-REx Ca2+ assays), Ki of 119 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | $758 | In stock | |
| 100 mg | Get quote |
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TAK-041 (Zelatriazin, NBI-1065846) is a potent, selective, brain-penetrant GPR139 agonist with EC50 of 22 nM (CHO-T-REx Ca2+ assays), Ki of 119 nM.
TAK-041 improves the social behavior in BALB/c mice, TAK-041 demonstrated GPR139-agonist-dependent modulation of habenula cell activity and revealed consistent in vivo efficacy to rescue social interaction deficits in the BALB/c mouse strain.
TAK-041 (NBI-1065846) is currently under development for treatment of negative symptoms in SCZ.
| M.Wt | 392.338 | |
| Formula | C18H15F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-(4-Oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide |
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1. Reichard HA, et al. J Med Chem. 2021 Aug 12;64(15):11527-11542.
2. Rabiner EA, et al. Neuropsychopharmacology. 2021 Oct 21.
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