TAK-041 (Zelatriazin, NBI-1065846) | GPR139 agonist

Chemical Structure : TAK-041

CAS No.: 1929519-13-0

TAK-041 (Zelatriazin, NBI-1065846, TAK041)

Catalog No.: PC-72146Not For Human Use, Lab Use Only.

TAK-041 (Zelatriazin, NBI-1065846) is a potent, selective, brain-penetrant GPR139 agonist with EC50 of 22 nM (CHO-T-REx Ca2+ assays), Ki of 119 nM.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$458	In stock
50 mg	$758	In stock
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Biological Activity

TAK-041 (Zelatriazin, NBI-1065846) is a potent, selective, brain-penetrant GPR139 agonist with EC50 of 22 nM (CHO-T-REx Ca2+ assays), Ki of 119 nM.
TAK-041 improves the social behavior in BALB/c mice, TAK-041 demonstrated GPR139-agonist-dependent modulation of habenula cell activity and revealed consistent in vivo efficacy to rescue social interaction deficits in the BALB/c mouse strain.
TAK-041 (NBI-1065846) is currently under development for treatment of negative symptoms in SCZ.

Physicochemical Properties

M.Wt	392.338
Formula	C18H15F3N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-Oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide

References

1. Reichard HA, et al. J Med Chem. 2021 Aug 12;64(15):11527-11542.

2. Rabiner EA, et al. Neuropsychopharmacology. 2021 Oct 21.

TAK-041 (Zelatriazin, NBI-1065846, TAK041)

Biological Activity

Physicochemical Properties

References

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