You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-TAK-063
TAK-063

Chemical Structure : TAK-063

CAS No.: 1238697-26-1

TAK-063 (TAK063;Balipodect)

Catalog No.: PC-43051Not For Human Use, Lab Use Only.

TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes.

Packing Price Stock Quantity
10 mg $98 In stock
25 mg $158 In stock
50 mg $248 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes.
TAK-063 increases cAMP and cGMP levels in the rodent striatum and upregulates phosphorylation levels of key substrates of cAMP- and cGMP-dependent protein kinases.
TAK-063 strongly suppresses MK-801-induced hyperlocomotion in rodents (0.3 and 1 mg/kg p.o), improves cognitive functions associated with schizophrenia in rodent models,

Physicochemical Properties

M.Wt 428.4185
Formula C23H17FN6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4(1H)-Pyridazinone, 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-

References

1. Kunitomo J, et al. J Med Chem. 2014 Nov 26;57(22):9627-43.

2. Suzuki K, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):471-9.

3. Shiraishi E, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):587-95.

4. Suzuki K, et al. Neuropsychopharmacology. 2016 Aug;41(9):2252-62.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: