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Chemical Structure : TAK-070
Catalog No.: PC-61042Not For Human Use, Lab Use Only.
TAK-070 (TAK070) is a selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays.
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TAK-070 (TAK070) is a selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays.
TAK-070 suppresses the secretion of Aβ with minimum effective concentrations (MECs) for Aβ40 and Aβ42 of 100 and 1000 nM respectively in human IMR-32 neuroblastoma cells.
TAK-070 also stimulates sAPPα production with MEC of 100 nM.
TAK-070 significantly decreases the secreted level of both human Swedish sAPPβ and mouse endogenous sAPPβ, N-terminal counterparts of APP generated by BACE1 cleavage, by ∼16 and ∼19% respectively at 3 uM.
TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.
| M.Wt | 440.02 | |
| Formula | C27H31NO.HCl.H2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fukumoto H, et al. J Neurosci. 2010 Aug 18;30(33):11157-66.
2. Takahashi H, et al. Brain Res. 2010 Nov 18;1361:146-56.
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