Chemical Structure : TAK-243
CAS No.:
1450833-55-2
TAK-243
(MLN7243;MLN-7243;AOB87172;AOB-87172)
Catalog No. : PC-60178Not For Human Use, Lab Use Only.
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1) with IC50 of 1 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6017801
Biological Activity
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1) with IC50 of 1 nM.
Physicochemical Properties
M.Wt
519.514
Formula
C19H20F3N5O5S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate
References
1. Wei J, et al. J Immunol.
2. Michael A. Milhollen, et al. DOI: 10.1158/1535-7163.
3. Barghout SH, et al. Leukemia.
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