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Chemical Structure : TAK-259
Catalog No.: PC-61508Not For Human Use, Lab Use Only.
TAK-259 is a potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM.
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TAK-259 is a potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM.
TAK-259 displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
TAK-259 shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.
| M.Wt | 374.236 | |
| Formula | C14H13Cl2N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.
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