TAK-259 | α1D adrenoceptor antagonist

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Adrenergic Receptor-TAK-259

Chemical Structure : TAK-259

TAK-259 (TAK259)

Catalog No.: PC-61508Not For Human Use, Lab Use Only.

TAK-259 is a potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TAK-259 is a potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM.
TAK-259 displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
TAK-259 shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.

Physicochemical Properties

M.Wt	374.236
Formula	C14H13Cl2N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide

References

1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

TAK-259 (TAK259)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.