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Chemical Structure : TAK-438
CAS No.: 1260141-27-2
Catalog No.: PC-60826Not For Human Use, Lab Use Only.
TAK-438 (Vonoprazan) is a novel potent, potassium-competitive acid blocker (P-CAB) that inhibits H(+),K(+)-ATPase activity in porcine gastric microsomes with IC50 of 19 nM at pH 6.5.
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| 500 mg | $58 | In stock | |
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TAK-438 (Vonoprazan) is a novel potent, potassium-competitive acid blocker (P-CAB) that inhibits H(+),K(+)-ATPase activity in porcine gastric microsomes with IC50 of 19 nM at pH 6.5.
The inhibitory activity of TAK-438 is unaffected by ambient pH, but not SCH28080 and lansoprazole.
TAK-438 completely inhibits basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats at 4 mg/kg (as the free base) orally;
TAK-438 is a more potent and longer-lasting inhibitory action on gastric acid secretion than either lansoprazole or SCH28080.
| M.Wt | 461.464 | |
| Formula | C21H20FN3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate |
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1. Arikawa Y, et al. J Med Chem. 2012 May 10;55(9):4446-56.
2. Hori Y, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):231-8.
3. Matsukawa J, et al. Biochem Pharmacol. 2011 May 1;81(9):1145-51.
4. Shin JM, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):412-20.
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