Catalog No.: PC-60826Not For Human Use, Lab Use Only.
TAK-438 (Vonoprazan) is a novel potent, potassium-competitive acid blocker (P-CAB) that inhibits H(+),K(+)-ATPase activity in porcine gastric microsomes with IC50 of 19 nM at pH 6.5.
TAK-438 (Vonoprazan) is a novel potent, potassium-competitive acid blocker (P-CAB) that inhibits H(+),K(+)-ATPase activity in porcine gastric microsomes with IC50 of 19 nM at pH 6.5.
The inhibitory activity of TAK-438 is unaffected by ambient pH, but not SCH28080 and lansoprazole.
TAK-438 completely inhibits basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats at 4 mg/kg (as the free base) orally;
TAK-438 is a more potent and longer-lasting inhibitory action on gastric acid secretion than either lansoprazole or SCH28080.
