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Chemical Structure : TAK-653
CAS No.: 1358751-06-0
Catalog No.: PC-22292Not For Human Use, Lab Use Only.
TAK-653 (NBI-1065845, Osavampator) is a potent, selective AMPA receptor positive allosteric modulator/potentiator, induces Ca2+ influx in hGluA1i CHO cells with EC50 of 2.2 uM.
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| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
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TAK-653 (NBI-1065845, Osavampator) is a potent, selective AMPA receptor positive allosteric modulator/potentiator, induces Ca2+ influx in hGluA1i CHO cells with EC50 of 2.2 uM.
TAK-653 exhibits minimal agonistic properties, binds to the ligand binding domain of recombinant AMPA-R in a glutamate-dependent manner.
TAK-653 strictly potentiated a glutamate-induced Ca2+ influx in hGluA1i-expressing CHO cells through structural interference at Ser743 in GluA1.
TAK-653 augmented AMPA-induced Ca2+ influx and AMPA-elicited currents via physiological AMPA-R with little agonistic effects in primary neurons.
TAK-653 enhanced electrically evoked AMPA-R-mediated EPSPs more potently than AMPA (agonist) or LY451646 (AMPA-R potentiator with a prominent agonistic effect) in brain slices.
TAK-653 improved cognition for both working memory and recognition memory.
| M.Wt | 373.47 | |
| Formula | C19H23N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
9-(4-(Cyclohexyloxy)phenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide |
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1. O'Donnell P, et al. Transl Psychiatry. 2021 May 27;11(1):325.
2. Suzuki A, et al. Sci Rep. 2021 Jul 21;11(1):15255.
3. Suzuki A, et al. Sci Rep. 2021 Jul 15;11(1):14532.
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