Chemical Structure : TAK-756
CAS No.:
TAK-756
(TAK756)
Catalog No.: PC-23560Not For Human Use, Lab Use Only.
TAK-756 is a potent, selective transforming growth factor β-activated kinase 1 (TAK1) inhibitor with pIC50 of 8.6, 464/60-fold selective over IRAK1/4.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TAK-756 is a potent, selective transforming growth factor β-activated kinase 1 (TAK1) inhibitor with pIC50 of 8.6, 464/60-fold selective over IRAK1/4.
TAK-756 exhibits a good selectivity score of 0.06 (S(50%)) in a panel of 330 kinases.
TAK-756 inhibits the phosphorylation of NF-κB, a downstream target of TAK1, with IC50 of 0.1 uM in SW982 cells upon activation with IL-1β.
TAK-756 dose-dependently decreases the expression levels of Cxcl1, Mmp3, and Il6 in meniscus, attenuates the inflammatory response triggered by an injection of monosodium urate (MSU) crystals and lipopolysaccharide (LPS) in the joint of naïve rats.
Physicochemical Properties
|
M.Wt
|
447.49
|
|
Formula
|
C25H25N3O5
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-(5-(6-((Cis-4-Hydroxycyclohexyl)oxy)-2-Methyl-1-Oxoisoindolin-5-yl)isoxazol-3-yl)benzamide
|
References
1. Langlois JB, et al. J Med Chem. 2024 Nov 22. doi: 10.1021/acs.jmedchem.4c01938.
Contact Us
sales@probechem.com
