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TAK-802 hydrochloride

Chemical Structure : TAK-802 hydrochloride

CAS No.: 263248-36-8

TAK-802 hydrochloride (TAK 802;TAK802)

Catalog No.: PC-61036Not For Human Use, Lab Use Only.

A potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM; exhibits high selectivity for acetylcholinesterase inhibition over butyrylcholinesterase inhibition; increases rhythmic bladder contractions in Guinea pigs and rats without affecting the basal intravesical pressure.

Other Indication

Phase 2 Discontinued

Physicochemical Properties

M.Wt 456.986
Formula C26H30ClFN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one hydrochloride

References

1. Ishichi Y, et al. Bioorg Med Chem. 2005 Mar 15;13(6):1901-11.

2. Nagabukuro H, et al. Eur J Pharmacol. 2004 Feb 6;485(1-3):299-305.

3. Nagabukuro H, et al. Eur J Pharmacol. 2004 Jun 28;494(2-3):225-32.

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