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Chemical Structure : TAK-875
CAS No.: 1000413-72-8
Catalog No.: PC-42610Not For Human Use, Lab Use Only.
TAK-875 (Fasiglifam) is a potent, selective, orally bioavailable GPR40 (FFA1) agonist with EC50 of 14 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $588 | In stock | |
| 250 mg | Get quote |
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TAK-875 (Fasiglifam) is a potent, selective, orally bioavailable GPR40 (FFA1) agonist with EC50 of 14 nM.
TAK-875 (Fasiglifam) exhibited excellent agonist potency selectivity over other FFA receptors (GPR41, GPR43, and GPR120, EC50s>10 uM).
TAK-875 (Fasiglifam) shows potent plasma glucose-lowering action and insulinotropic action in vivo.
| M.Wt | 524.6252 | |
| Formula | C29H32O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 128 mg/mL |
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| Chemical Name/SMILES |
3-Benzofuranacetic acid, 6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-, (3S)- |
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1. Negoro N, et al. ACS Med Chem Lett. 2010 Jun 18;1(6):290-4.
2. Tsujihata Y, et al. J Pharmacol Exp Ther. 2011 Oct;339(1):228-37.
3. Yashiro H, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):483-9.
4. Ito R, et al. Br J Pharmacol. 2013 Oct;170(3):568-80.
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