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Chemical Structure : TAK-915
CAS No.: 1476727-50-0
Catalog No.: PC-60563Not For Human Use, Lab Use Only.
TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.
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|---|---|---|---|
| 2 mg | $458 | In stock | |
| 5 mg | $758 | In stock | |
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TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.
TAK-915 dispalys 4100-fold selectivity over PDE1A, and >20,000-fold over other PDE isoforms.
TAK-915 robustly increased cGMP levels in the rat brain, attenuates MK-801-induced episodic memory deficits in rats.
| M.Wt | 458.37 | |
| Formula | C19H18F4N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((1S)-1-(3-fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide |
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1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.
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