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TAOK inhibitor 43

Chemical Structure : TAOK inhibitor 43

CAS No.: 850467-66-2

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TAOK inhibitor 43

Catalog No.: PC-62730Not For Human Use, Lab Use Only.

TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively.
    TAOK inhibitor 43 increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles.
    TAOK inhibitor 43 induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models.

    Physicochemical Properties

    M.Wt
    Formula C25H24N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide

    References

    1. Koo CY, et al. Mol Cancer Ther. 2017 Nov;16(11):2410-2421.

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