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TAOK inhibitor 63

Chemical Structure : TAOK inhibitor 63

CAS No.: 850467-91-3

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TAOK inhibitor 63

Catalog No.: PC-62818Not For Human Use, Lab Use Only.

TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively.
    TAOK inhibitor 63 increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindle.
    TAOK inhibitor 63  induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models.

    Physicochemical Properties

    M.Wt 488.562
    Formula C26H24N4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-{3-[(2-{[6-methoxy-1,3-benzothiazol-2-yl]amino}-2-oxoethyl)amino]-3-oxo-1-phenylpropyl}benzamide

    References

    1. Koo CY, et al. Mol Cancer Ther. 2017 Nov;16(11):2410-2421.

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