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TAS-204

Chemical Structure : TAS-204

CAS No.: 920286-12-0

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TAS-204 (TAS204)

Catalog No.: PC-49642Not For Human Use, Lab Use Only.

TAS-204 (TAS204) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, inhibits recombinant human H-PGDS with IC50 of 24.0 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TAS-204 (TAS204) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, inhibits recombinant human H-PGDS with IC50 of 24.0 nM.
    TAS-204 showed no inhibitory activities against COX-1, COX-2, microsomal PGE synthase or L-PGDS up to 10 uM.
    TAS204 at 3.75, 7.5, 15 and 30 mg/kg dose-dependently inhibited the PGD2 production in in vivo.
    TAS-204 reduced osinophil infiltration in nasal lavage fluid and nasal hyperresponsiveness to histamine in guinea pig model of experimental allergic rhinitis.

    Physicochemical Properties

    M.Wt 438.91
    Formula C23H23ClN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride

    References

    1. Daisuke Kajiwara, et al. Eur J Pharmacol. 2011 Sep 30;667(1-3):389-95.

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