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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Glycine Transporter (GlyT)-TASP0315003
TASP0315003

Chemical Structure : TASP0315003

CAS No.:

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TASP0315003 (TASP-0315003, TP0439150)

Catalog No.: PC-61459Not For Human Use, Lab Use Only.

A potent, selective, orally available GlyT1 inhibitor with IC50 of 1.6 nM, weakly inhibits rat GlyT2 (IC50=138 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TASP0315003 (TP0439150) is a potent, selective, orally available GlyT1 inhibitor with IC50 of 1.6 nM, weakly inhibits rat GlyT2 (IC50=138 nM).
    TASP0315003 (TP0439150) shows no activities at 107 other receptors, transporters, and ion channels, including NMDA, dopamine, serotonin and opioid receptors.
    TASP0315003 (TP0439150) significantly improves MK-801 impaired cognition, and also enhanced social memory in rats, reduces social interaction induced by repeated phencyclidine (PCP) in mice.
    TASP0315003 (TP0439150) also exhibits an antidepressant effect in rats, does not cause sedation or motor dysfunction.

    Physicochemical Properties

    M.Wt 491.943
    Formula C24H25ClF3N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    References

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