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Chemical Structure : TASP0376377
Catalog No.: PC-61564Not For Human Use, Lab Use Only.
TASP0376377 is a potent, selective prostaglandin D2 receptor (CRTH2) antagonist with binding IC50 of 19 nM.
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TASP0376377 is a potent, selective prostaglandin D2 receptor (CRTH2) antagonist with binding IC50 of 19 nM.
TASP0376377 shows excellent functional antagonist activity in chemotaxis assay with IC50 of 23 nM, displays sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor (IC50>1 yM), COX-1 and COX-2 enzymes (IC50>10 uM).
| M.Wt | 479.313 | |
| Formula | C25H16Cl2N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nishikawa-Shimono R, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3305-10.
2. Nishikawa-Shimono R, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7674-85.
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