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TASP0376377

Chemical Structure : TASP0376377

CAS No.: 1233246-60-0

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TASP0376377 (TASP 0376377)

Catalog No.: PC-61564Not For Human Use, Lab Use Only.

TASP0376377 is a potent, selective prostaglandin D2 receptor (CRTH2) antagonist with binding IC50 of 19 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TASP0376377 is a potent, selective prostaglandin D2 receptor (CRTH2) antagonist with binding IC50 of 19 nM.
    TASP0376377 shows excellent functional antagonist activity in chemotaxis assay with IC50 of 23 nM, displays sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor (IC50>1 yM), COX-1 and COX-2 enzymes (IC50>10 uM).

    Physicochemical Properties

    M.Wt 479.313
    Formula C25H16Cl2N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(1-(4-(3,4-dichlorobenzamido)benzoyl)isoquinolin-4-yl)acetic acid

    References

    1. Nishikawa-Shimono R, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3305-10.

    2. Nishikawa-Shimono R, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7674-85.

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