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Chemical Structure : TBC3486
Catalog No.: PC-61261Not For Human Use, Lab Use Only.
TBC3486 is a potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM, displays 200-fold selectivity over α4β7 (IC50=2.1 uM).
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TBC3486 is a potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM, displays 200-fold selectivity over α4β7 (IC50=2.1 uM).
TBC3486 mimics VCAM-1 binding, preferentially inhibits the high-affinity form of the integrin α4, blocks integrin-dependent T-cell co-activation in vitro as well as proves to be efficacious in vivo at low doses in animal models of allergic inflammation.
TBC3486 dose-dependently inhibits adhesion of ALL cells, prolongs the survival of xenotolerant mice bearing human leukemia cells in vivo.
| M.Wt | 557.68 | |
| Formula | C27H31N3O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hsieh YT, et al. Leukemia. 2014 Oct;28(10):2101-4.
2. Vanderslice P, et al. Biochem Biophys Res Commun. 2010 Oct 1;400(4):619-24.
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