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Chemical Structure : TBI-223
CAS No.: 2071265-08-0
Catalog No.: PC-20073Not For Human Use, Lab Use Only.
TBI-223 is an oxazolidinone with excellent oral bioavailability and activity against Gram-positive bacteria, works as protein synthesis inhibitor, targets an early step involving the binding of N-formylmethionyl-tRNA to the ribosome.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | $898 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TBI-223 is an oxazolidinone with excellent oral bioavailability and activity against Gram-positive bacteria, works as protein synthesis inhibitor, targets an early step involving the binding of N-formylmethionyl-tRNA to the ribosome.
TBI-223 showed reduced human and mouse bone marrow progenitor cell toxicity in vitro and bone marrow toxicity in rat and dog models in vivo, compared to linezolid.
TBI-223 had broader efficacy against other antibiotic-resistant Gram-positive bacteria, including vancomycin-resistant enterococci, penicillin- and ceftriaxone-resistant Streptococcus pneumoniae, and coagulase-negative staphylococci
TBI-223 had activity in vitro and in vivo against other bacteria, such as drug-sensitive and drug-resistant Mycobacterium tuberculosis.
TBI-223 had significant efficacy against MRSA infections, including in bacteremia, nondiabetic and diabetic skin wound infections, and OIAI.
TBI-223 had efficacy comparable to that of linezolid in all of the mouse models of bacteremia, nondiabetic and diabetic skin wound models, and OIAI.
| M.Wt | 365.36 | |
| Formula | C17H20FN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
methyl (S)-((3-(3-fluoro-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)carbamate |
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1. Gordon O, et al. Microbiol Spectr. 2022 Oct 26;10(5):e0245121.
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