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Chemical Structure : TBK1 PROTAC 1
CAS No.: 2052306-13-3
Catalog No.: PC-60484Not For Human Use, Lab Use Only.
TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.
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TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.
TBK1 PROTAC 1 is a chemical tool to assess TBK1 as a target in mutant K-Ras cancer cells.
| M.Wt | 1093.193 | |
| Formula | C53H74BrN9O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,4R)-1-((S)-18-(4-((5-bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
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1. Crew AP, et al. J Med Chem. 2017 Jul 10. doi: 10.1021/acs.jmedchem.7b00635.
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