TBK1 PROTAC 1 |CAS:2052306-13-3 Probechem Biochemicals

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Chemical Structure : TBK1 PROTAC 1

CAS No.: 2052306-13-3

TBK1 PROTAC 1 (TBK1 PROTAC 3i)

Catalog No.: PC-60484Not For Human Use, Lab Use Only.

TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.
TBK1 PROTAC 1 is a chemical tool to assess TBK1 as a target in mutant K-Ras cancer cells.

Physicochemical Properties

M.Wt	1093.193
Formula	C53H74BrN9O9S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-18-(4-((5-bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

References

1. Crew AP, et al. J Med Chem. 2017 Jul 10. doi: 10.1021/acs.jmedchem.7b00635.

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TBK1 PROTAC 1 (TBK1 PROTAC 3i)

Biological Activity

Physicochemical Properties

References

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