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Chemical Structure : TC-E 5005
Catalog No.: PC-61347Not For Human Use, Lab Use Only.
TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM.
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TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM.
TC-E 5005 displays 30-500-fold selectivity over PDE10A, 2A, 11A, 5A, 7B and 3A, shows no inhibitory activity for PDE1B, 4A, 6, 8A and 9A (IC50>5 uM).
TC-E 5005 reverses stereotypy and hyperactivity induced by MK-801 in rats.
TC-E 5005 also inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate, inhibits neurogenic contractions with similar efficacy than tadalafil.
| M.Wt | 270.33 | |
| Formula | C15H18N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Höfgen N, et al. J Med Chem. 2010 Jun 10;53(11):4399-411.
2. Hennenberg M, et al. Prostate. 2016 Nov;76(15):1364-74.
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