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TC-E 5005

Chemical Structure : TC-E 5005

CAS No.: 959705-64-7

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TC-E 5005 (TCE-5005, TC-E-5005)

Catalog No.: PC-61347Not For Human Use, Lab Use Only.

TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM.
    TC-E 5005 displays 30-500-fold selectivity over PDE10A, 2A, 11A, 5A, 7B and 3A, shows no inhibitory activity for PDE1B, 4A, 6, 8A and 9A (IC50>5 uM).
    TC-E 5005 reverses stereotypy and hyperactivity induced by MK-801 in rats.
    TC-E 5005 also inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate, inhibits neurogenic contractions with similar efficacy than tadalafil.

    Physicochemical Properties

    M.Wt 270.33
    Formula C15H18N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine

    References

    1. Höfgen N, et al. J Med Chem. 2010 Jun 10;53(11):4399-411.

    2. Hennenberg M, et al. Prostate. 2016 Nov;76(15):1364-74.

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