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Chemical Structure : TC-I 15
CAS No.: 916734-43-5
Catalog No.: PC-62071Not For Human Use, Lab Use Only.
TC-I 15 is a highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TC-I 15 is a highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM.
TC-I 15 inhibits adhesion of cells expressing wild-type (WT) and demonstrates no effect on RBL cells expressing an activating I-domain mutation (E318A).
TC-I 15 inhibits an activating cytoplasmic domain mutant [Del(GFFKR)] with an IC50 ≈4-fold higher than for wild-type integrin α2β1.
TC-I 15 shows efficacious activity in an animal model of arterial thrombosis.
| M.Wt | 520.619 | |
| Formula | C23H28N4O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-(3-benzylureido)-2-((R)-5,5-dimethyl-3-(phenylsulfonyl)thiazolidine-4-carboxamido)propanoic acid |
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1. Miller MW, et al. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24.
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