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TCP2 inhibitor 163

Chemical Structure : TCP2 inhibitor 163

CAS No.: 1448808-10-3

TCP2 inhibitor 163 (Deazaflavin 163)

Catalog No.: PC-20288Not For Human Use, Lab Use Only.

TCP2 inhibitor 163 (Deazaflavin 163) is a potent, selective inhibitor of tyrosyl-DNA-phosphodiesterases 2 (TDP2) with EC50 of 40 nM in NPPP assays, shows selectivity against TDP1 and APE-1.

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    Biological Activity

    TCP2 inhibitor 163 (Deazaflavin 163) is a potent, selective inhibitor of tyrosyl-DNA-phosphodiesterases 2 (TDP2) with EC50 of 40 nM in NPPP assays, shows selectivity against TDP1 and APE-1.

    Physicochemical Properties

    M.Wt 382.34
    Formula C19H10N8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    10-(3-(1H-tetrazol-5-yl)phenyl)-2,4-dioxo-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile

    References

    1. Raoof A, et al. J Med Chem. 2013 Aug 22;56(16):6352-70.

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