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TCS2210

Chemical Structure : TCS2210

CAS No.: 1201916-31-5

TCS2210 (TCS 2210, TCS-2210)

Catalog No.: PC-22433Not For Human Use, Lab Use Only.

TCS2210 is a selective inhibitor of IRAK1 (SPR Kd=1.76 uM) and inducer of neuronal differentiation in mesenchymal stem cells, suppresses the growth of epithelial ovarian cancer (EOC) cells.

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Biological Activity

TCS2210 is a selective inhibitor of IRAK1 (SPR Kd=1.76 uM) and inducer of neuronal differentiation in mesenchymal stem cells, suppresses the growth of epithelial ovarian cancer (EOC) cells.
TCS2210 displays clean selectivity against a set of 468 human kinases and disease-relevant mutants.
TCS2210 suppresses IRAK1 expression within 24 h in A1847 and OVCAR8 cells.
TCS2210 inhibits cell viability of A2780, A1847, OVCAR8, and OVCAR3 cells with IC50 of 20 uM, induces apoptosis of EOC cells. TCS2210 significantly inhibited EOC growth in vitro and in vivo both as monotherapy, and in combination with cisplatin.

Physicochemical Properties

M.Wt 323.35
Formula C18H17N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2-Dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide

References

1. David Standing, et al. Cell Death Dis. 2024 May 25;15(5):362.

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