Chemical Structure : TCV-309 chloride
CAS No.: 121494-09-5
Catalog No.: PC-45596Not For Human Use, Lab Use Only.
A highly potent and selective platelet activating factor (PAF) antagonist.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $280 | In stock | |
10 mg | $400 | In stock | |
50 mg | $1200 | In stock | |
100 mg | $1680 | In stock |
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A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively; potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively; also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.
Coagulation Disorder
Phase 2 Discontinued
M.Wt | 629.9724 | |
Formula | C30H34BrClN4O4 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 6.3 mg/mL |
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Chemical Name/SMILES |
Pyridinium, 3-bromo-5-[[[3-[[2-[[(3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]oxy]ethyl]amino]-3-oxopropyl]phenylamino]carbonyl]-1-propyl-, chloride (1:1) |
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2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67.
3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
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