Catalog No.: PC-28090Not For Human Use, Lab Use Only.
Fimosudil hydrochloride (TDI01, TDI01470) is a potent, highly selective Rho-associated coiled-coil containing kinase 2 (ROCK2) inhibitor with IC50 of 10.31 nM, 598-fold selectivity over ROCK1.
Fimosudil hydrochloride (TDI01, TDI01470) is a potent, highly selective Rho-associated coiled-coil containing kinase 2 (ROCK2) inhibitor with IC50 of 10.31 nM, 598-fold selectivity over ROCK1.
TDI01 exhibits high-affinity binding to ROCK2 (KD=65.56 nM) in BLI assays, with negligible binding to ROCK1 up to 60 uM.
TDI01 exhibits dose-dependent inhibition of ROCK2 activity in ECs and LX2 cells.
TDI01 (5 mg/kg, oral) decreased serum ALT and AST levels, lowered hepatic HYP content, alleviated liver collagen deposition, and reduced steatosis in mouse MASH model.
TDI01 is at least partially mediated by attenuating the production of pro-fibrotic galectin-3 from liver ECs.
