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Chemical Structure : TDO2 inhibitor LM10
CAS No.: 1316695-35-8
Catalog No.: PC-49667Not For Human Use, Lab Use Only.
LM10 is a relatively specific, competitive inhibitor of tryptophan 2,3-dioxygenase 2 (TDO2) with Ki of 5.6 uM and IC50 of 0.62 uM (hTDO), does not inhibit IDO.
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|---|---|---|---|
| 25 mg | $248 | In stock | |
| 100 mg | $758 | In stock | |
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LM10 is a relatively specific, competitive inhibitor of tryptophan 2,3-dioxygenase 2 (TDO2) with Ki of 5.6 uM and IC50 of 0.62 uM (hTDO), does not inhibit IDO.
LM10 (160 mg/kg/day) prevented the growth of TDO-expressing P815 tumor cells.
LM10 treatment exhibited marginal effect in inhibiting the growth of PDAC in vivo.
| M.Wt | 229.22 | |
| Formula | C11H8FN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole |
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1. Dolusić E, et al. J Med Chem. 2011;54:5320–5334.
2. L. Pilotte, et al. Proc. Natl. Acad. Sci. U.S.A. 109, 2497–2502 (2012).
3. Chengcao Sun, et al. Sci Adv. 2023 Feb 3;9(5):eadd6995.
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