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Chemical Structure : TEAD activator Q2
Catalog No.: PC-20409Not For Human Use, Lab Use Only.
TEAD activator Q2 (Quinolinol Q2) is a small molecule activator of TEAD with EC50 of 2.6 uM in TEAD dual-luciferase reporter (DLR) assays, inhibits TEAD-palmitate interaction with IC50 of 1.7 uM.
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TEAD activator Q2 (Quinolinol Q2) is a small molecule activator of TEAD with EC50 of 2.6 uM in TEAD dual-luciferase reporter (DLR) assays, inhibits TEAD-palmitate interaction with IC50 of 1.7 uM.
Quinolinol Q2 directly binds to TEAD with SPR Kd of 2.6 uM, significantly enhances the expression levels of YAP/TAZ-TEAD target genes.
Quinolinol Q2 accelerates cutaneous wound healing in mice, activates nuclear YAP and enhances cell proliferation within days 4-5 postwounding.
| M.Wt | 349.43 | |
| Formula | C21H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ajaybabu V Pobbati, et al. ACS Chem Biol. 2019 Dec 20;14(12):2909-2921.
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