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TEAD inhibitor 6

Chemical Structure : TEAD inhibitor 6

CAS No.: 2714432-83-2

TEAD inhibitor 6

Catalog No.: PC-20405Not For Human Use, Lab Use Only.

TEAD inhibitor 6 is a highly potent TEAD inhibitor, disrupts the YAP-TEAD interaction with IC50 of 2.7 nM, binds the main interaction site of YAP at the surface of TEAD.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TEAD inhibitor 6 is a highly potent TEAD inhibitor, disrupts the YAP-TEAD interaction with IC50 of 2.7 nM, binds the main interaction site of YAP at the surface of TEAD.

Physicochemical Properties

M.Wt 470.93
Formula C25H24ClFN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((2S)-2-(aminomethyl)-5-chloro-2-phenyl-2,3-dihydrobenzofuran-4-yl)-3-fluoro-4-(2-methoxyethoxy)benzamide

References

1. Pascal Furet, et al. ChemMedChem. 2022 Oct 6;17(19):e202200303.

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