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Chemical Structure : TED-347
CAS No.: 2378626-29-8
Catalog No.: PC-35898Not For Human Use, Lab Use Only.
TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $758 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM).
TED-347 inhibits its binding to Yap1, blocked its transcriptional activity; inhibits TEAD transcriptional activity and protein interactions in cells at 5 uM resulted in over 70% reduction in reporter activity.
TED-347 inhibits GBM43 cancer cell viability by 30% at 10 uM, also inhibits TEAD4 transcriptional activity in GBM43 cells.
| M.Wt | 313.704 | |
| Formula | C15H11ClF3NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one |
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1. Bum-Erdene K, et al. Cell Chem Biol. 2018 Dec 18. pii: S2451-9456(18)30432-X.
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