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Chemical Structure : TED-642
Catalog No.: PC-49697Not For Human Use, Lab Use Only.
TED-642 (TED642) is a potent, covalent, pan-TEAD-YAP1 antagonist, inhibits TEAD1/2/4 binding to YAP with IC50 of 0.9-1.2 uM.
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TED-642 (TED642) is a potent, covalent, pan-TEAD-YAP1 antagonist, inhibits TEAD1/2/4 binding to YAP with IC50 of 0.9-1.2 uM.
TED-642 forms a covalent bond with the central pocket cysteine of TEADs (TEAD4, Cys-367).
TED-642 inhibited the binding of FAM-YAP1 60-99 to TEAD4 with an IC50 of 1.1 uM, with similar IC50 values for TEAD1 and TEAD2 to FAM-YAP 60-99.
TED-642 inhibits TEAD transcriptional activity (CTGF transcript level) in breast cancer cell MDA-MB-468 with IC50 of 0.6 uM, inhibits TEAD1-4 transcriptional activity in HEK-293 cells with IC50 of 2.2-5.1 uM.
TED-642 inhibits cell proliferation of osteosarcoma cell lines SaOS-2 and SaOS-LM7 with IC50 of 0.1 and 0.2 uM, respectively.
| M.Wt | 303.29 | |
| Formula | C16H12F3N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bum-Erdene K, et al. J Med Chem. 2023 Jan 12;66(1):266-284.
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