Chemical Structure : TED-655
CAS No.:
TED-655
(TED655)
Catalog No.: PC-26510Not For Human Use, Lab Use Only.
TED-655 is a small-molecule covalent inhibitor of TEAD-YAP1 transcription factor, reduces TEAD and YAP1 protein levels.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TED-655 is a small-molecule covalent inhibitor of TEAD-YAP1 transcription factor, reduces TEAD and YAP1 protein levels.
TED-655 binds to the TEAD lipid pocket and form a covalent bond with a conserved cysteine.
TED-655 inhibits transcriptional activity of all four TEADs.
TED-655 (10 uM) shows a subtle but concentration-dependent reduction of TEAD and YAP1 protein levels in MDA-MB-231, MPNST 90-8, and SaOS-LM7 cells.
TED-655 shows no effect on TEAD1 or YAP1 mRNA levels, suggesting that reduction in protein levels of TEAD and YAP1 is likely post-translational.
TED-655 inhibits cancer cell proliferation with IC50 in the single-digit micromolar range for NCI-H226.
Physicochemical Properties
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M.Wt
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332.33
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Formula
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C18H15F3N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-((4-(trifluoromethyl)phenyl)amino)isoindolin-2-yl)prop-2-en-1-one
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References
1. Yeh, I. J.; Bum-Erdene, K.; Ghozayel, M. K.; Gonzalez-Gutierrez, G.; Meroueh, S. O. Small-Molecule Covalent Stabilization and Inhibition of the TEAD.YAP1 Transcription Factor in Cancer Cells. ACS Chem. Biol. 2025, 20, 2142– 2158
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