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TFC-007

Chemical Structure : TFC-007

CAS No.: 927878-49-7

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TFC-007 (TFC007)

Catalog No.: PC-49640Not For Human Use, Lab Use Only.

TFC-007 (TFC007) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 83 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TFC-007 (TFC007) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 83 nM.
    TFC-007 displays negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.
    TFC-007 (30mg/kg, p.o.) given once before a challenge almost completely suppressed PGD(2) production in the nasal tissue early and late after the challenge.

    Physicochemical Properties

    M.Wt 487.56
    Formula C27H29N5O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide

    References

    1. Nabe T, et al. Prostaglandins Other Lipid Mediat. 2011 Aug;95(1-4):27-34.

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