TG100-115 (TG100115) is a potent, selective PI3Kγ/δ with IC50 of 83/235 nM, respectively.
TG100-115 shows no significant inhibitory activity against pI3Kα and β, and a broad panel of kinases (IC50>1 uM).
TG100-115 potently inhibits edema and inflammation in response to multiple mediators known to participate in myocardial infarction, such as VEGF and platelet-activating factor, without effect on endothelial cell mitogenesis。
TG100-115 provides potent cardioprotection, reduces infarct development and preserves myocardial function in animal MI models.
Physicochemical Properties
M.Wt
346.3428
Formula
C18H14N6O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Phenol, 3,3'-(2,4-diamino-6,7-pteridinediyl)bis-
References
1. Doukas J, et al. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.
