Catalog No.: PC-42432Not For Human Use, Lab Use Only.
TG100572 hydrochloride is a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family.
TG100572 hydrochloride is a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family.
TG100572 inhibits vascular endothelial cell proliferation in vitro (ED50=610 nM) and blocks VEGF-induced phosphorylation of ERK。
TG100572 induces apoptosis; significant suppresses laser-induced choroidal neovascularization (CNV) in a murine model.
