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Chemical Structure : TG 100572 hydrochloride
CAS No.: 867331-64-4
Catalog No.: PC-42432Not For Human Use, Lab Use Only.
TG100572 hydrochloride is a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TG100572 hydrochloride is a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family.
TG100572 inhibits vascular endothelial cell proliferation in vitro (ED50=610 nM) and blocks VEGF-induced phosphorylation of ERK。
TG100572 induces apoptosis; significant suppresses laser-induced choroidal neovascularization (CNV) in a murine model.
| M.Wt | 512.4309 | |
| Formula | C26H27Cl2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 44 mg/mL |
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| Chemical Name/SMILES |
Phenol, 4-chloro-3-[5-methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-1,2,4-benzotriazin-7-yl]-, hydrochloride (1:1) |
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1. Doukas J, et al. J Cell Physiol. 2008 Jul;216(1):29-37.
2. Sharma S, et al. J Virol. 2011 Jun;85(12):5995-6007.
3. Palanki MS, et al. J Med Chem. 2008 Mar 27;51(6):1546-59.
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