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Chemical Structure : TG 100801 hydrochloride
CAS No.: 1018069-81-2
Catalog No.: PC-42434Not For Human Use, Lab Use Only.
The prodrug of TG 100572, a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $304 | In stock | |
| 50 mg | $768 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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The prodrug of TG 100572, a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family; significantly suppresses laser-induced CNV in mice, and reduces fluorescein leakage from the vasculature and retinal thickening in a rat model of retinal vein occlusion (topical administration).
| M.Wt | 616.5369 | |
| Formula | C33H31Cl2N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Phenol, 4-chloro-3-[5-methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-1,2,4-benzotriazin-7-yl]-, 1-benzoate, hydrochloride (1:1) |
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1. Doukas J, et al. J Cell Physiol. 2008 Jul;216(1):29-37.
2. Sharma S, et al. J Virol. 2011 Jun;85(12):5995-6007.
3. Palanki MS, et al. J Med Chem. 2008 Mar 27;51(6):1546-59.
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