TG4-155 is a potent and selective prostaglandin EP2 receptor antagonist with Kb of 2.4 nM.
TG4-155 displays 4,730-fold selectivity over EP4, >500-fold selectivity over human BLT1, EP1, EP3, and FP receptors, and 7-fold selectivity against human DP1 receptor.
TG4-155 displays robust inhibition of PGE2-induced cAMP accumulation in C6G cells stably expressing mouse EP2 receptor.
TG4-155 significantly reduces SE-induced neurodegeneration in mice.
