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TGN1412

Chemical Structure : TGN1412

CAS No.:

TGN1412 (Anti-human CD28 mAb, human IgG4P-Kappa)

Catalog No.: PC-Ab1030Not For Human Use, Lab Use Only.

TGN1412 is a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. TGN1412 binds to the laterally exposed C′D loop of CD28 and demonstrated its therapeutic potential for use in autoimmune disease, led to a massive and uncontrolled release of proinflammatory cytokines (cytokine storm) during clinical phase I trials..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TGN1412 is a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. TGN1412 binds to the laterally exposed C′D loop of CD28 and demonstrated its therapeutic potential for use in autoimmune disease, led to a massive and uncontrolled release of proinflammatory cytokines (cytokine storm) during clinical phase I trials.

Physicochemical Properties

M.Wt
Formula Human IgG4P-Kappa
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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