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TGP-377/421

Chemical Structure : TGP-377/421

CAS No.: 16752-89-9

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TGP-377/421 (Targapre-miR-377/421)

Catalog No.: PC-72390Not For Human Use, Lab Use Only.

TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.

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5 mg $138 In stock
10 mg $228 In stock
25 mg $388 In stock
50 mg $598 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.
TGP-377/421 inhibits the cellular biogenesis of miR-377 in HUVECs, reduced mature miR-377 levels in a dose-dependent fashion with IC50 of 5 uM, also inhibits miR-421.

Physicochemical Properties

M.Wt 340.39
Formula C20H16N6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-(6-amino-1H-benzo[d]imidazol-2-yl)phenyl)-1H-benzo[d]imidazol-5-amine

References

1. Hafeez S Haniff, et al. Nat Chem. 2020 Oct;12(10):952-961.

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