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TGR-1202 R-enantiomer

Chemical Structure : TGR-1202 R-enantiomer

CAS No.: 1532533-69-9

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TGR-1202 R-enantiomer (RP5264 R-enantiomer;TGR1202 R-enantiomer)

Catalog No.: PC-42943Not For Human Use, Lab Use Only.

TGR-1202 R-enantiomer is is the less active enantiomer of TGR-1202 (Umbralisib), TGR-1202 is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 22 nM..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TGR-1202 R-enantiomer is is the less active enantiomer of TGR-1202 (Umbralisib), TGR-1202 is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 22 nM.

Physicochemical Properties

M.Wt 571.5492
Formula C31H24F3N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4H-1-Benzopyran-4-one, 2-[(1R)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)-

References

1. Locatelli SL, et al. Leukemia. 2016 Dec;30(12):2402-2405.

2. Deng C, et al. Blood. 2017 Jan 5;129(1):88-99.

3. Burris HA 3rd, et al. Lancet Oncol. 2018 Feb 20. pii: S1470-2045(18)30082-2.

4. Lampson BL, et al. Expert Opin Investig Drugs. 2017 Nov;26(11):1267-1279.

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