TGX-221 |CAS:663619-89-4 Probechem Biochemicals

Chemical Structure : TGX-221

CAS No.: 663619-89-4

TGX-221 (TGX221;TGX 221)

Catalog No.: PC-42325Not For Human Use, Lab Use Only.

TGX-221 is a potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.

Packing	Price	Stock
10 mg	$108	In stock
25 mg	$178	In stock
50 mg	$298	In stock
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Biological Activity

TGX-221 is a potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.
TGX-221 weakly inhibits p110δ (IC50=211 nM), and no activity against p110α (IC50>1 uM).
TGX-221 inhibits platelet-ECC interaction, platelet aggregation and platelet-granulocyte binding。
TGX-221 shows anti-thrombotic effectt devoid of other cardiovascular actions in rats.

Physicochemical Properties

M.Wt	364.4409
Formula	C21H24N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-Pyrido[1,2-a]pyrimidin-4-one, 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-

References

1. Frazzetto M, et al. Biochem J. 2008 Sep 15;414(3):383-90.

2. Sturgeon SA, et al. Eur J Pharmacol. 2008 Jun 10;587(1-3):209-15.

3. Chaussade C, et al. Biochem J. 2007 Jun 15;404(3):449-58.

4. Straub A, et al. Thromb Haemost. 2008 Mar;99(3):609-15.

TGX-221 (TGX221;TGX 221)

Biological Activity

Physicochemical Properties

References

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