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TH5427

Chemical Structure : TH5427

CAS No.: 2253744-56-6

TH5427 (TH-5427, TH 5427)

Catalog No.: PC-62517Not For Human Use, Lab Use Only.

TH 5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX hydrolase type 5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TH5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX hydrolase type 5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro.
TH5427 shows little to no effect on NUDT9, dCTPase, NUDT12 and NUDT14.
TH5427 inhibits progestin-dependent nuclear ATP synthesis, subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.
TH5427 is a potent NUDT5 inhibitor that blocks hormone-dependent gene expression in breast cancer cells.

Physicochemical Properties

M.Wt 491.333
Formula C20H20Cl2N8O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-((5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-1,3-dimethyl-8-(piperazin-1-yl)-3,7-dihydro-1H-purine-2,6-dione

References

1. Page BDG, et al. Nat Commun. 2018 Jan 17;9(1):250.

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