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Chemical Structure : TH8321
CAS No.:
Catalog No.: PC-72496Not For Human Use, Lab Use Only.
TH8321 (TH-8321) is a potent, selective NUDT15 inhibitor with IC50 of 35 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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TH8321 (TH-8321) is a potent, selective NUDT15 inhibitor with IC50 of 35 nM.
TH8321 demonstrated satisfactory selectivity among a panel of related proteins, including NUDT22, NUDT18, NUDT12, NUDT9, NUDT5, NUDT2, MTH1, ITPase, dCTPase, and dUTPase.
TH8321 potently engaged and inhibited cellular NUDT15, TH8321 (5 uM) substantially potentiated the anti-HCMV efficacy of ganciclovir in HCMV infected MRC-5 cells, recapitulating the effect of NUDT15 knockdown.
| M.Wt | 355.46 | |
| Formula | C18H21N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-amino-9-cyclohexyl-8-(2-methoxyphenyl)-3,9-dihydro-6H-purine-6-thione |
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1. Si Min Zhang, et al. Cell Chem Biol. 2021 Dec 16;28(12):1693-1702.e6.
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