Catalog No.: PC-60381Not For Human Use, Lab Use Only.
THPN is a potent specific agonist of nuclear receptor TR3 (Nur77) with Kd of 270 nM for Nur77 LDB, induces melanoma autophagy through a mitochondrial signaling pathway.
THPN is a potent specific agonist of nuclear receptor TR3 (Nur77) with Kd of 270 nM for Nur77 LDB, induces melanoma autophagy through a mitochondrial signaling pathway.
THPN binds TR3 to facilitate the interaction with Nix, induces TR3 localization to MIM.
THPN significantly represses tumor growth in xenograft mouse model.
THPN is a chemical probe to study TR3-mediated signal transduction pathway.
Physicochemical Properties
M.Wt
266.34
Formula
C15H22O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-(3,4,5-Trihydroxyphenyl)nonan-1-one
References
1. Wang WJ, et al. Chem Biol. 2015 Aug 20;22(8):1040-51.
2. Wang WJ, et al. Nat Chem Biol. 2014 Feb;10(2):133-40.
