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THPN

Chemical Structure : THPN

CAS No.: 100079-26-3

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THPN

Catalog No.: PC-60381Not For Human Use, Lab Use Only.

THPN is a potent nuclear receptor TR3 (Nur77)-specific targeting compound that can induce melanoma autophagy through a mitochondrial signaling pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    THPN is a potent nuclear receptor TR3 (Nur77)-specific targeting compound that can induce melanoma autophagy through a mitochondrial signaling pathway.
    THPN binds TR3 to facilitate the interaction with Nix, induces TR3 localization to MIM.
    THPN significantly represses tumor growth in xenograft mouse model.
    THPN is a chemical probe to study TR3-mediated signal transduction pathway.

    Physicochemical Properties

    M.Wt 266.34
    Formula C15H22O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3,4,5-Trihydroxyphenyl)nonan-1-one

    References

    1. Wang WJ, et al. Chem Biol. 2015 Aug 20;22(8):1040-51.

    2. Wang WJ, et al. Nat Chem Biol. 2014 Feb;10(2):133-40.

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