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Chemical Structure : THPN
Catalog No.: PC-60381Not For Human Use, Lab Use Only.
THPN is a potent nuclear receptor TR3 (Nur77)-specific targeting compound that can induce melanoma autophagy through a mitochondrial signaling pathway.
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THPN is a potent nuclear receptor TR3 (Nur77)-specific targeting compound that can induce melanoma autophagy through a mitochondrial signaling pathway.
THPN binds TR3 to facilitate the interaction with Nix, induces TR3 localization to MIM.
THPN significantly represses tumor growth in xenograft mouse model.
THPN is a chemical probe to study TR3-mediated signal transduction pathway.
| M.Wt | 266.34 | |
| Formula | C15H22O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang WJ, et al. Chem Biol. 2015 Aug 20;22(8):1040-51.
2. Wang WJ, et al. Nat Chem Biol. 2014 Feb;10(2):133-40.
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