THRβ agonist 14q

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Chemical Structure : THRβ agonist 14q

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Catalog No.: PC-27284Not For Human Use, Lab Use Only.

THRβ agonist 14q is a potent, selective agonist of thyroid hormone receptor β (THRβ) with EC50 of 36 nM, with no discernible activity against THRα.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

THRβ agonist 14q is a potent, selective agonist of thyroid hormone receptor β (THRβ) with EC50 of 36 nM, with no discernible activity against THRα.
THRβ agonist 14q possesses excellent metabolic stability across species and favorable oral pharmacokinetics in mice.
THRβ agonist 14q significantly ameliorated hepatic steatosis, serum biomarkers, and liver gene expression profiles in murine MASH model, without observable cardiac toxicity.

Physicochemical Properties

M.Wt	438.61
Formula	C17H9Cl3F3NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,6-dichloro-5-((2-chloro-3-(trifluoromethyl)benzyl)oxy)-1H-indole-2-carboxylic acid

References

1. Bo Wang, et al. J Med Chem. 2026 Jul 1. doi: 10.1021/acs.jmedchem.6c01478.

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