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THRX-144644

Chemical Structure : THRX-144644

CAS No.: 2442519-59-5

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THRX-144644 (THRX144644)

Catalog No.: PC-38197Not For Human Use, Lab Use Only.

THRX-144644 (THRX144644) is a potent, lung-selective ALK5 inhibitor with IC50 of 0.14 nM, inhibits p-SMAD3 in a BEAS2B cell line with IC50 of 23 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    THRX-144644 (THRX144644) is a potent, lung-selective ALK5 inhibitor with IC50 of 0.14 nM, inhibits p-SMAD3 in a BEAS2B cell line with IC50 of 23 nM。
    THRX-144644 displays high selectivity in a broad secondary pharmacology panel with exception of e Lymphocyte CellSpecific Protein-Tyrosine Kinase (LCK, IC50=140 nM).
    THRX-144644 demonstrated favorable TGFβ pathway pharmacodynamic inhibition in lung while minimizing key systemic toxicities.

    Physicochemical Properties

    M.Wt 512.006
    Formula C26H28ClF2N7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(3-(5-chloro-2,4-difluorophenyl)-1H-pyrazol-4-yl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)-1,5-naphthyridin-3-amine

    References

    1. Jonathan Maher, et al. Toxicol Appl Pharmacol. 2022 Feb 2;115905.

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