THRX-198321 |CAS:743460-20-0 Probechem Biochemicals

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Chemical Structure : THRX-198321

THRX-198321 (THRX198321)

Catalog No.: PC-63038Not For Human Use, Lab Use Only.

THRX-198321 is a bifunctional mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.69/10.05 for M1/M2 respectively, pEC50 of 9.25 for β2AR.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

THRX-198321 is a bifunctional mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.69/10.05 for M1/M2 respectively, pEC50 of 9.25 for β2AR.
THRX-198321 exhibits a multivalent bimodal orientation in the orthosteric and allosteric binding pockets of mAChR and β(2)AR.

Physicochemical Properties

M.Wt	640.825
Formula	C38H48N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Biphenyl-2-yl-carbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-5-yl)-ethylamino]-nonyl}-piperidin-4-yl ester

References

1. Steinfeld T, et al. Mol Pharmacol. 2011 Mar;79(3):389-99.

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THRX-198321 (THRX198321)

Biological Activity

Physicochemical Properties

References

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