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THRX-200495

Chemical Structure : THRX-200495

CAS No.: 1442690-58-5

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THRX-200495 (THRX 200495;THRX200495)

Catalog No.: PC-61049Not For Human Use, Lab Use Only.

THRX-200495 is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.21/9.53 for hM2/M3, pKi of 9.37 for β2-adrenoceptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    THRX-200495 is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.21/9.53 for hM2/M3, pKi of 9.37 for β2-adrenoceptor.
    THRX-200495 demonstrates potent, balanced and long-lasting bronchodilation in a guinea pig model of bronchoprotection that is greater than either the MA or BA mechanisms alone

    Physicochemical Properties

    M.Wt 752.912
    Formula C46H48N4O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(3-(4-(4-(2-((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)ethyl)phenoxy)phenyl)propyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

    References

    1. McNamara A, et al. Pulm Pharmacol Ther. 2012 Oct;25(5):357-63.

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