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Chemical Structure : THRX-200495
Catalog No.: PC-61049Not For Human Use, Lab Use Only.
THRX-200495 is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.21/9.53 for hM2/M3, pKi of 9.37 for β2-adrenoceptor.
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THRX-200495 is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.21/9.53 for hM2/M3, pKi of 9.37 for β2-adrenoceptor.
THRX-200495 demonstrates potent, balanced and long-lasting bronchodilation in a guinea pig model of bronchoprotection that is greater than either the MA or BA mechanisms alone
| M.Wt | 752.912 | |
| Formula | C46H48N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McNamara A, et al. Pulm Pharmacol Ther. 2012 Oct;25(5):357-63.
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