THZ-2-118 |CAS:1644498-54-3 Probechem Biochemicals

Chemical Structure : THZ-2-118

THZ-2-118 (IRAK1 inhibitor)

Catalog No.: PC-38076Not For Human Use, Lab Use Only.

THZ-2-118 is a potent selective inhibitor of IRAK1 with IC50 of 14.2 nM.

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Biological Activity

THZ-2-118 is a potent selective inhibitor of IRAK1 with IC50 of 14.2 nM.
THZ-2-118 does not inhibitor IRAK4 at 10 uM, also potently inhibits JNK1/2/3 (IC50=1-2 nM).

Physicochemical Properties

M.Wt	493.571
Formula	C28H27N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(4-(dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

References

1. Hatcher JM, et al. ACS Med Chem Lett. 2020 Oct 9;11(11):2238-2243.

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THZ-2-118 (IRAK1 inhibitor)

Biological Activity

Physicochemical Properties

References

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