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Chemical Structure : TIM-063
Catalog No.: PC-72949Not For Human Use, Lab Use Only.
TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.
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TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.
TIM-063 directly targets the catalytic domain of CaMKK, similar to STO-609.
TIM-063 suppressed the ionomycin-induced phosphorylation of exogenously expressed CaMKI, CaMKIV, and endogenous AMPKα in HeLa cells with an IC50 of 0.3 uM.
TIM-063 suppressed CaMKK isoform-mediated CaMKIV phosphorylation in transfected COS-7 cells.
TIM-063 displayed cell permeability and the ability to inhibit CaMKK activity in cells.
TIM-063 is a useful chemical probe for the precise analysis of CaMKK-mediated signaling pathways.
| M.Wt | 331.287 | |
| Formula | C18H9N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ohtsuka S, et al. Biochemistry. 2020 May 5;59(17):1701-1710.
2. Satomi Ohtsuka, et al. Biochemistry, March 11, 2022.
3. Toshio Kitazawa, et al. Am J Physiol Cell Physiol. 2021 Sep 1;321(3):C549-C558.
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